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Scientists have mentioned limiting the antioxidant results of selenium might assist stop the unfold of triple detrimental breast most cancers.
The motion of selenium, a key antioxidant discovered in foods corresponding to Brazil nuts, meat, mushrooms and cereals, was assumed to be helpful in combating towards most cancers cells.
The new research challenges this.
The analysis, revealed in EMBO Molecular Medicine, exhibits that when triple detrimental breast most cancers cells are not clustered collectively, corresponding to after they are shifting to different components of the physique, they can not survive with out selenium.
Research lead Dr Saverio Tardito, of the Cancer Research UK Scotland Institute in Glasgow, explains: “We need selenium to survive, so, removing it from our diet is not an option, however, if we can find a treatment that interferes with the uptake of this mineral by triple negative breast cancer cells, we could potentially prevent this cancer spreading to other parts of the body.”
But what precisely is selenium, and what meals is it in?
What is selenium?
“Selenium is a trace element found in soil,” explains Dr Carrie Ruxton, a dietitian at the Health and Food Supplements Information Service. “In the body, selenium is well absorbed and is used to make a protein building-block (amino acid) called selenocysteine.
“Proteins made from this amino acid are vital for normal thyroid function, immunity, fertility and also protecting the body against cancers and cell damage due to toxins.”
What meals is it in?
“Unfortunately, the UK has historically low levels of selenium in our soils, making our cereals poor sources,” says Ruxton. “So, we need to choose animal foods (turkey thigh, beef), fish (tuna) or imported foods (Brazil nuts are the richest source) to get what we need from the diet.
“A simple alternative is to top up with a multivitamin and multi-mineral supplement which will provide recommended doses of the nutrients we need on a daily basis. This complements our diets and doesn’t replace the natural sources of selenium.”
What are the well being advantages of selenium?
Selenium is a strong antioxidant.
“Every day our body cells are under attack from free radicals produced during the normal activities of our metabolism and immune system,” explains Ruxton. “Cells need a constant supply of antioxidants, including selenium, vitamins C and E, to protect them.”
This important nutrient additionally performs an necessary function in sustaining thyroid operate.
“Correct levels of selenium helps maintain the thyroid and protect its tissue, while a deficiency may increase the risk of thyroid disease,” explains Lucy Diamond, registered dietitian and scientific director for Innovation at NHS weight administration supplier, Oviva.
Findings from some research additionally recommend that it might additionally assist decrease ldl cholesterol.
“According to studies, selenium can help to protect against cardiovascular disease by lowering ‘bad’ cholesterol and inflammation,” says Ruxton. “There may also be a role in cancer prevention and protecting against cognitive decline, but the evidence is inconsistent.”
Does any proof present that an excessive amount of selenium is unhealthy?
Despite its advantages, consuming an excessive amount of selenium over a chronic interval can be poisonous, explains Diamond.
“This condition is called selenosis, and it can lead to symptoms like hair loss, brittle nails, garlic-like breath, and digestive issues,” says Diamond. “In extreme cases, it can even cause more serious problems, like nerve damage.
“It’s not a common issue for most people, especially if you’re getting selenium through food, but it’s something to be mindful of if you’re taking supplements or regularly eating large amounts of selenium-rich foods like Brazil nuts.”
So how a lot should we be consuming?
“In general, men aged 19-64 years are recommended 75μg a day and women aged 19-64 years are recommended 60μg a day per day, but that amount can vary slightly depending on life stages, such as pregnancy or breastfeeding,” says Diamond. “Not getting enough selenium can lead to issues like weakened immunity or cognitive changes, though deficiency is fairly rare.
“However, too much selenium isn’t good either, so it’s important to be mindful of the upper limit of 400 mcg per day, as overdoing it can lead to negative side effects like hair loss or digestive problems.”
Ruxton says that consuming three or 4 Brazil nuts a day is lots, and encourages folks taking dietary dietary supplements to at all times observe the dosage directions.
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